The beginnings of the Department of Systematic Theology reach as far as to the work of Karel Statečný who gave lectures on Ethics and Systematic Theology to students from a seminary of the Czechoslovak Church at the Hussite Czechoslovak Protestant Theological Faculty in 1924-1927. After the reorganization of the Hussite Czechoslovak Theological Faculty, Alois Spisar was the head of the Systematical Theology section of the Department for the Czechoslovak Church. When the Faculty was divided in 1950, Zdeněk Trtík was also active at the new Hus Czechoslovak Faculty as the head systematic theologian until 1979. The Department was then taken over by Zdeněk Kučera who remained in this position after 1990 when the Faculty was incorporated into Charles University as the Hussite Theological Faculty. Jiří Vogel is currently the head of the department.

The Department does not only educate students of Theological fields of study but it also contributes to teaching other non-theological study programs at the Hussite theological faculty. The members of the Department pursue pedagogical as well as scientific activities in Dogmatic Theology, Modern Theology, Ethics, Theological Philosophy and the relationship between Religion and Natural Sciences.